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The editors of the journal Osteoarthritis and Cartilage announce a request for original research papers for a special themed issue addressing “Innate Immunity in OA”. 

The Pre-Competitive Consortium for OA (PCCOA) was created by OARSI more than a decade ago in response to a Federal Register Notice seeking a critical appraisal on a number of questions that would help to inform the updating of the 1999 guidance for Clinical Development Programs for the Treatment and Prevention OA.  Subsequently in 2016, OARSI submitted a White Paper to the FDA providing a comprehensive review and rationale for OA to be defined as a potentially serious disease and to demonstrate that evidence from numerous data analyses provided justification for consideration of the use of surrogate markers in studies of some patients with OA for the early approval...

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