Is Virtual
Virtual
Category
Webinar
Title: Inflammatory and Metabolic Mechanisms in Osteoarthritis
Presenter: Changhai Ding, MD, PhD
Moderator: Kim Bennell, PhD, University of Melbourne, Australia
Session Description: Osteoarthritis is a chronic disease with multiple underlying mechanisms and no-disease modifying therapy so far. Experimental and observational studies have revealed that inflammatory and/or metabolic cytokines, adipokines, signalling pathways, cells and MRI-measured effusion-synovitis are all related to osteoarthritis, indicating there exist inflammatory and/or metabolic phenotypes of osteoarthritis. Recent clinical trials suggests targeting inflammatory mechanism using methotrexate would have an effect on inflammatory hand osteoarthritis, and targeting metabolic mechanism using metformin and semaglutide would have effects on metabolic osteoarthritis; however, a recent clinical trial failed to find significant effects of methotrexate on inflammatory knee osteoarthritis.
Presenter information:
Dr Changhai Ding is a Professor and Director of Clinical Research Centre, Zhujiang Hospital at Southern Medical University, China. He is also an Adjunct Professor at University of Tasmanian, and Monash University, Australia. He is the Chair of Research & Training Committee and a former Board Member of Osteoarthritis Research Society International (OARSI). He has focused on the epidemiological and clinical studies in osteoarthritis and osteoporosis, and has published over 350 manuscripts in international peer-reviewed journals including JAMA, Nature Reviews Disease Primers and JAMA Internal Medicine.