Leptin, an adipokine with pleiotropic activities, has been the subject of innovative research into the pathogenesis of osteoarthritis. It is of interest due to its role at the interface between metabolism and immune homeostasis. We have received a commentary by Dr. Virginia Kraus that discusses the role of leptin in osteoarthritis and proposes an often-overlooked connection between leptin and high-density lipoprotein (HDL) cholesterol. We co-published two commentaries that offer somewhat contrasting views, and we invite you to join the debate online - a new feature of Osteoarthritis and Cartilage. We hope you will share your views or additional information with the community.