CONCLUSION: Serum cytokines are stable over time. Antibiotic treatment had little effect. Some cytokines may be associated with intensity of lower back pain 📈 oarsijournal.com/article/S10…
RESULTS: Five cytokines changed from baseline -> one year. CCL21 and IL-6 were modulated by Amoxicillin. Lower back pain modulated levels of four serum cytokines 🤒
METHODS: Amoxicillin was administered (placebo controlled) and 39 serum cytokines were measured at baseline and one year 🕐
OBJECTIVE: Gjefsen et al. investigated longitudinal cytokine changes, as well as changes after antibiotic treatment 💊
Serum cytokine changes in patients with low back pain, a 🧵👇
🔥off the press: THE ILLUSION OF EFFECTIVENESS
Size of regression to the mean in a typical trial for knee OA corresponds to improvement of about 1 NRS pain point!
shorturl.at/ftEOY
@ClinEpi_LU @OACJournal @OARSInews @OARSI_YI @ORSsociety #osteoarthritis @artrosportalen
Our basic and clinical science #EditorsChoice papers chosen by @AM_Malf and @ProfDavidHunter are free to read for the month of April. Check them out on the OAC website
oarsijournal.com
Both in vitro and in vivo studies included in this systematic review provide evidence to demonstrate beneficial effects of Ang II receptor antagonists on osteoarthritis and cartilage defect models across animal species.
bit.ly/3JMpvRl
Submit your proposals for the 30th Anniversary Special Edition of OAC
Original research, reviews from basic and clinical science welcome @ProfDavidHunter @AM_Malf
doi.org/10.1016/j.joca.2023.…
Uncovering the “riddle of femininity” in #osteoarthritis: a systematic review and meta-analysis of menopausal animal models and mathematical modeling of estrogen treatment
bit.ly/3ZehMB7
Read the systematic review by Pacheco-Brousseau in @OACJournal
doi.org/10.1016/j.joca.2023.…
Read Gillian's editorial in @OACJournal
doi.org/10.1016/j.joca.2023.…
On this week's episode we are joined by Dr Gillian Hawker @UofTDoMChair to discuss the appropriateness of joint replacement surgery for #osteoarthritis
🎧 Listen at pod.fo/e/1748a0
In @OACJournal, our team including Dr. Collins (@CollJamie), Ms. Yang, our RA Maame, and Dr. Losina co-authored this paper that showed most OAI participants showed at least one relevant increase in WOMAC pain over the study period bit.ly/418Ylv3
Gene transfer of human TGF-β1 with recombinant adeno-associated virus vectors reduces perifocal #osteoarthritis and improves osteochondral repair at long term in a large animal model 🦴
bit.ly/42L3hYw
Congratulations Andy on your recent publication in @OACJournal: “Effect of molecular weight and tissue layer on solute partitioning in the knee meniscus.” Paper in collaboration with Gabi Schwartz, Dr. Best, Dr. Travascio, and Dr. Jackson. @EngineerUMiami
sciencedirect.com/science/ar…
I'm so excited to moderate Reza's talk next week! It's really cool to see some of these novel Epi methods applied to OA research.
@srjafarz and @Tuhina_Neogi published a great overview on this method in @OACJournal last year - oarsijournal.com/article/S10…
Original research and reviews welcome-basic and clinical
Morning stiffness >60 minutes present in 1/5 patients with #hand #osteoarthritis
Morning stiffness associated with
➡️More pain
➡️Worse physical function
➡️Reduced quality of life
👉🏽sciencedirect.com/science/ar…
via @OACJournal
📣 Submit your proposals for the 3⃣0⃣th Anniversary Special Edition of OAC
✨ Proposals are due on April 30, 2023
@AM_Malf @ProfDavidHunter @stephfilbay @OARSInews @OARSI_YI
doi.org/10.1016/j.joca.2023.…
